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JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a JWH-018 (AM-678) at both the CB and CB cannabinoid receptors, with some selectivity for CB It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as legal cannabis herbal incense blends” which in some countries are sold legally as incense, labeled not for human consumption

What is JWH 018 used for?
JWH-018, also called a synthetic cannabinoid, is an emerging drug of choice to replace the use of Marijuana. Since it provides the same effect or even better than Marijuana, most herbal smoke blends incorporate JWH-018 as part of the ingredients to achieve a better high experience.

At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 has been shown to cause profound changes in CB receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.

On October 15, 2011, Anderson County Coroner Greg Shore attributed the death of a South Carolina college basketball player to “drug toxicity and organ failure” caused by JWH-018. An email dated Nov 4, 2011, concerning the case was finally released by the city of Anderson S.C. on Dec 16, 2011, under the Freedom of Information Act after multiple requests by media to see the information had been denied.

Cannabis abuse and dependence remains a worldwide problem. A series of cannabinoids originally synthesized by Huffman et al., (2005), labeled as JWH, have entered the recreational market. Highly purified JWH compounds, which are more readily synthesized than plant-derived cannabinoids, are available from online vendors in gram quantities with no age verification. Herbal blends infused with these compounds (e.g., Spice) is being sold in “head shops” and smoked despite warnings that the products are not intended for human consul

One female and three male adult rhesus monkeys (Macaca mulatta) discriminated Δ9-THC from the vehicle and one male and two female rhesus monkeys discriminated rimonabant during chronic Δ9-THC (1 mg/kg s.c. 12 h) treatment. Monkeys were housed individually on a 14-h light/10-h dark schedule and maintained at 95% free-feeding weight (range 5.8–10.4 kg) with a diet consisting of primate chow (High Protein Monkey Diet; Harlan Teklad, Madison, WI), fresh fruit, and peanuts; water was provided in the home cage. Monkeys received cannabinoids and noncannabinoids in previous studies


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